Rebuttal to: strong lupus anticoagulant can influence the prothrombin time INR falsifying the follow up of oral anticoagulation.

نویسندگان

  • Els Bailleul
  • Kristien Van Vaerenbergh
  • Antoon Lust
چکیده

1. Weiler H, Isermann BH. Thrombomodulin. J Thromb Haemost 2003; 1: 1515–24. 2. McCachren SS, Diggs J, Weinberg JB et al. Thrombomodulin expression by human blood monocytes and by human synovial tissue lining macrophages. Blood 1991; 78: 3128–32. 3. Satta N, Freyssinet JM, Toti F. The significance of human monocyte thrombomodulin during membrane vesiculation and after stimulation by lipopolysaccharide. Br J Haematol 1997; 96: 534–42. 4. Wu KK, Aleksic N, Ahn C et al. Thrombomodulin Ala455Val polymorphism and risk of coronary heart disease. Circulation 2001; 103: 1386–9. 5. Le Flem L, Mennen L, Aubry ML et al. Thrombomodulin promoter mutations, venous thrombosis, and varicose veins. Arterioscler Thromb Vasc Biol 2001; 21: 445–51. 6. Reny JL, Laurendeau I, Fontana P et al. The TF-603A/G gene promoter polymorphism and circulating monocyte tissue factor gene expression in healthy volunteers. Thromb Haemost 2004; 91: 248–54. 7. Santucci RA, Erlich J, Labriola J et al. Measurement of tissue factor activity in whole blood. Thromb Haemost 2000; 83: 445–54.

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منابع مشابه

Interference of lupus anticoagulants in prothrombin time assays: implications for selection of adequate methods to optimize the management of thrombosis in the antiphospholipid-antibody syndrome.

BACKGROUND AND OBJECTIVE Prolonged anticoagulation aiming at International Normalized Ratio (INR) values > 3.0 has been recommended for patients with thrombosis and the antiphospholipid-antibody syndrome. We evaluated the influence of anticoagulant antibodies in two different prothrombin time (PT) assays carried out on plasma from lupus anticoagulant patients on oral anticoagulation. DESIGN A...

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The aim was to determine the validity of the international normalized ratio (INR) and prothrombin time (PT) as a monitor for warfarin therapy in patients with lupus anticoagulants and recurrent thrombosis, and to investigate alternative approaches to monitoring warfarin therapy and new treatment options in these patients. A case is described of a 63-year-old female with antiphospholipid syndrom...

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Emergency reversal of anticoagulation with a three-factor prothrombin complex concentrate in patients with intracranial haemorrhage.

BACKGROUND Intracranial haemorrhage is a serious and potentially fatal complication of oral anticoagulant therapy. Prothrombin complex concentrates can substantially shorten the time needed to reverse the effects of oral anticoagulants. The aim of this study was to determine the efficacy and safety of a prothrombin complex concentrate for rapid reversal of oral anticoagulant therapy in patients...

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Factor X and factor II activity levels do not always agree in warfarin-treated lupus anticoagulant patients.

Warfarin therapy is used in lupus anticoagulant patients with thrombosis and yet the prothrombin time (PT)/international normalized ratio (INR) in these patients can sometimes be falsely elevated. Both a PT-based factor II (FII) assay and a chromogenic, enzymatic factor X (CFX) assay have been used for monitoring when the INR may be artifactual. This study compared FII and CFX assays in lupus a...

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Point-of-care monitoring of oral anticoagulation therapy in children. Comparison of the CoaguChek XS system with venous INR and venous INR using an International Reference Thromboplastin preparation (rTF/95).

Point-of-care (POC) monitoring of oral anticoagulation has been widely adopted in both paediatric and adult patients. A new POC system, the CoaguChek XS has recently been developed to measure the international normalised ratio (INR) and may offer significant advantages. The CoaguChek XS utilises a new method of electrochemical clot detection based on thrombin generation. This system has not bee...

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عنوان ژورنال:
  • Thrombosis and haemostasis

دوره 94 3  شماره 

صفحات  -

تاریخ انتشار 2005